Previously, we showed that GATA-4 is a potential marker for malignant yolk sac endoderm in pediatric germ cell tumors. This highly malignant tissue can cause

Uterine smooth muscle tumors of uncertain malignant potential (STUMP) represent a group of rare and challenging leiomyoma neoplasms. Knowledge of these tumors continues to evolve as information emerges about pathology, molecular genetics, and recurrence rates.

smooth muscle tumors presenting as mediastinal soft tis-. sue masses were studied and correlated with their clini-. cal behavior. Tissues were examined histologically and. with immunohistochemical stains in all cases, and by.

Cutaneous leiomyosarcomas frequently reoccur following excision, but rarely metastasize. MALIGNANT smooth-muscle tumors (leiomyosarcomas) of soft-tissue origin are rare tumors, as indicated by the fact that in a review of the recent surgical literature, only one series, comprising 36 c BACKGROUND: Nearly 80% of patients with malignant uterine smooth muscle tumor will suffer local relapse and/or distant metastases after initial surgical resection. There is no convincing evidence that the addition of pelvic radiation improves the outcome. However, adjuvant chemotherapy might be an appropriate therapeutic modality. Smooth muscle tumor of uncertain malignant potential, abbreviated STUMP, is an uncommon tumor of the uterine smooth muscle that may behave like a benign tumor or a cancerous tumor. This tumor should not be confused with the prostatic stromal tumor of uncertain malignant potential which may be abbreviated the same way (STUMP). 1980-07-01 · On microscopy the tumor consisted of interlacing smooth muscle bundles.

Aniridia - Wilms tumor, syndrome Dystrophy:muscular, facio-scapulo-humeral. Dystrophy: muscular Malignant osteopetrosis. Malignant Nephroblastoma - fetal ascitis - tumor syndrome Smooth muscle dysfunction syndrome. SNEL.

DDX: other spindle cell tumors such as sarcomatoid carcinoma (keratin+), stromal sarcoma (CD34+, actin-), GIST (c-kit+) and SFT (CD34+, actin-). A uterine leiomyosarcoma is a rare malignant (cancerous) tumor that arises from the smooth muscle lining the walls of the uterus (myometrium).

Malignant muscle tumors are called leiomyosarcomas and rhabdomyosarcomas. Muscles are of 2 types namely smooth muscles and skeletal muscles.

Cutaneous leiomyomas (leiomyoma cutis) are the most common group of benign smooth muscle tumors, with two types.

2. Deep leiomyoma. 3. Genital leiomyoma. B. Malignant tumors . Abstract. Uterine smooth muscle tumors of uncertain malignant potential (STUMP ) represent a group of rare and challenging leiomyoma neoplasms.
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14 The smooth muscle nature of the cells can be confirmed with the Masson trichrome stain or the use of immunoperoxidase markers for smooth muscle such as vimentin, smooth muscle actin (SMA), desmin, and caldesmon. 39 SMA is more specific for smooth muscle than panactin HHF35.

Malignant smooth muscle tumor. Typically spindle cell, but can be epithelioid. Want to see: 1) High-grade cytologic atypia, 2) Increased mitoses (typically >2/10 HPF), and 3) Tumor-type necrosis Genetically complex chromosomal aberrations Very poor prognosis Endometrial Stromal Tumors Low-grade/benign tumors stain like normal endometrial stroma Malignant tumor of smooth muscle: Leiomysarcoma. Muscle connected to internal organs: Visceral.
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Smooth muscle tumors of the uterus are very common and the vast majority are benign leiomyomas. In contrast, leiomyosarcomas are rare and constitute only 1.3% of uterine malignancies (Figure 19.1). Nevertheless, leiomyosarcoma is the most frequent malignant mesenchymal tumor of the uterus, accounting for almost 60% of uterine sarcomas.

Pleomorphic or epithelioid cases may require desmin or caldesmon reactivity to support smooth muscle differentiation Any one of the following is sufficient to diagnose a smooth muscle tumor as malignant for the stated sites Cytologic pleomorphism or atypia A uterine leiomyosarcoma is a rare malignant (cancerous) tumor that arises from the smooth muscle lining the walls of the uterus (myometrium). There are essentially two types of muscles in the body: voluntary and involuntary. Smooth muscles are involuntary muscles; the brain has no conscious control over them.

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Sarcomas of the female genital tract are rare tumors and account for less than 5% of gynecologic malignancies. Traditionally, gynecologic sarcomas have been

1). Convalescence was uneventful and no further therapy was given. Coagulative tumor cell necrosis: abrupt transition between necrotic cells and preserved cells; ghost outlines of nuclei of necrotic cells are often seen in necrotic area, but inflammatory cells are uncommon; common in clinically malignant smooth muscle tumors - DON'T IGNORE. 2020-08-01 · In addition to the categories proposed by Bell et al. for tumors belonging to an indeterminate category, the WHO classification system has defined a tumor of uncertain malignant potential as "a smooth muscle tumor with features that preclude an unequivocal diagnosis of leiomyosarcoma, but do not fulfill the criteria for leiomyoma, or its variants, and raises concern that the neoplasm may behave in a malignant fashion". Elongate eosinophilic cytoplasm Pleomorphic or epithelioid cases may require desmin or caldesmon reactivity to support smooth muscle differentiation Any one of the following is sufficient to diagnose a smooth muscle tumor as malignant for the stated sites Cytologic pleomorphism or atypia Smooth muscle tumors of the uterus are very common and the vast majority are benign leiomyomas.